Characterization of the peptide-binding specificity of Mamu-A*11 results in the identification of SIV-derived epitopes and interspecies cross-reactivity
Identifieur interne : 003013 ( Main/Exploration ); précédent : 003012; suivant : 003014Characterization of the peptide-binding specificity of Mamu-A*11 results in the identification of SIV-derived epitopes and interspecies cross-reactivity
Auteurs : Alessandro Sette [États-Unis] ; John Sidney [États-Unis] ; Huynh-Hoa Bui [États-Unis] ; Marie-France Del Guercio [États-Unis] ; Jeff Alexander [États-Unis] ; John Loffredo [États-Unis] ; David I. Watkins [États-Unis] ; Bianca R. Mothé [États-Unis]Source :
- Immunogenetics [ 0093-7711 ] ; 2005-04-01.
Descripteurs français
- Wicri :
- topic : Sida.
English descriptors
Abstract
Abstract: The SIV-infected Indian rhesus macaque is the most established model of HIV infection, providing insight into pathogenesis and a system for testing novel vaccines. However, only a limited amount of information is available regarding the peptide-binding motifs and epitopes bound by their class I and class II MHC molecules. In this study, we utilized a library of over 1,000 different peptides and a high throughput MHC-peptide binding assay to detail the binding specificity of the rhesus macaque class I molecule Mamu-A*11. These studies defined the fine specificity of primary anchor positions, and dissected the role of secondary anchors, for peptides of 8–11 residues in length. This detailed information was utilized to develop size-specific polynomial algorithms to predict Mamu-A*11 binding capacity. Testing SIVmac239-derived Mamu-A*11 binding peptides for recognition by peripheral blood mononuclear cells (PBMC) from Mamu-A*11-positive, SIV-infected macaques, identified five novel SIV-derived Mamu-A*11 epitopes. Finally, we detected extensive cross-reactivity at the binding level between Mamu-A*11 and the mouse H-2 class I molecule Kk. Further experiments revealed that three out of four Mamu-A*11 binding peptides which bound Kk and were immunogenic in Kk mice were also recognized in Mamu-A*11-infected macaques. This is the first detailed description of mouse-macaque interspecies cross-reactivity, potentially useful in testing novel vaccines in mice and macaques.
Url:
DOI: 10.1007/s00251-004-0749-z
Affiliations:
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Mothé</name><affiliation wicri:level="1"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Biological Sciences, California State University, San Marcos, 92096, San Marcos, CA</wicri:regionArea><wicri:noRegion>CA</wicri:noRegion></affiliation><affiliation wicri:level="1"><country wicri:rule="url">États-Unis</country></affiliation></author></analytic><monogr></monogr><series><title level="j">Immunogenetics</title><title level="j" type="abbrev">Immunogenetics</title><idno type="ISSN">0093-7711</idno><idno type="eISSN">1432-1211</idno><imprint><publisher>Springer-Verlag; http://www.springer.de</publisher><pubPlace>Berlin/Heidelberg</pubPlace><date type="published" when="2005-04-01">2005-04-01</date><biblScope unit="volume">57</biblScope><biblScope unit="issue">1-2</biblScope><biblScope unit="page" from="53">53</biblScope><biblScope unit="page" to="68">68</biblScope></imprint><idno type="ISSN">0093-7711</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0093-7711</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>AIDS</term><term>Epitope</term><term>MHC</term><term>Macaque</term><term>SIV</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Sida</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Abstract: The SIV-infected Indian rhesus macaque is the most established model of HIV infection, providing insight into pathogenesis and a system for testing novel vaccines. However, only a limited amount of information is available regarding the peptide-binding motifs and epitopes bound by their class I and class II MHC molecules. In this study, we utilized a library of over 1,000 different peptides and a high throughput MHC-peptide binding assay to detail the binding specificity of the rhesus macaque class I molecule Mamu-A*11. These studies defined the fine specificity of primary anchor positions, and dissected the role of secondary anchors, for peptides of 8–11 residues in length. This detailed information was utilized to develop size-specific polynomial algorithms to predict Mamu-A*11 binding capacity. Testing SIVmac239-derived Mamu-A*11 binding peptides for recognition by peripheral blood mononuclear cells (PBMC) from Mamu-A*11-positive, SIV-infected macaques, identified five novel SIV-derived Mamu-A*11 epitopes. Finally, we detected extensive cross-reactivity at the binding level between Mamu-A*11 and the mouse H-2 class I molecule Kk. Further experiments revealed that three out of four Mamu-A*11 binding peptides which bound Kk and were immunogenic in Kk mice were also recognized in Mamu-A*11-infected macaques. This is the first detailed description of mouse-macaque interspecies cross-reactivity, potentially useful in testing novel vaccines in mice and macaques.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Sette, Alessandro" sort="Sette, Alessandro" uniqKey="Sette A" first="Alessandro" last="Sette">Alessandro Sette</name></noRegion><name sortKey="Alexander, Jeff" sort="Alexander, Jeff" uniqKey="Alexander J" first="Jeff" last="Alexander">Jeff Alexander</name><name sortKey="Bui, Huynh Hoa" sort="Bui, Huynh Hoa" uniqKey="Bui H" first="Huynh-Hoa" last="Bui">Huynh-Hoa Bui</name><name sortKey="Del Guercio, Marie France" sort="Del Guercio, Marie France" uniqKey="Del Guercio M" first="Marie-France" last="Del Guercio">Marie-France Del Guercio</name><name sortKey="Loffredo, John" sort="Loffredo, John" uniqKey="Loffredo J" first="John" last="Loffredo">John Loffredo</name><name sortKey="Mothe, Bianca R" sort="Mothe, Bianca R" uniqKey="Mothe B" first="Bianca R." last="Mothé">Bianca R. Mothé</name><name sortKey="Mothe, Bianca R" sort="Mothe, Bianca R" uniqKey="Mothe B" first="Bianca R." last="Mothé">Bianca R. Mothé</name><name sortKey="Sidney, John" sort="Sidney, John" uniqKey="Sidney J" first="John" last="Sidney">John Sidney</name><name sortKey="Watkins, David I" sort="Watkins, David I" uniqKey="Watkins D" first="David I." last="Watkins">David I. Watkins</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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